GetClockCalibration was fixed four months ago, please make sure you're using an up to date build of both wine and vkd3d-proton (and please post some sort of log file next time that includes wine console output).
Is PROTON_LOG=1 a good source for logs?
This is the log for Proton-5.21-GE-1 though I'm having the same issue with Proton-5.13-2. They both should come with a pretty recent version of vkd3d though I could try to build one from master.
In the log I could find the following:
fixme:d3d12_command_queue_GetClockCalibration: QPC domain not supported by device, timestamp calibration may be inaccurate.
256:err:d3d12_command_queue_GetClockCalibration: Querying calibrated timestamps failed, vr -13.
256:fixme:hresult_from_vk_result: Unhandled VkResult -13.
293.624:00fc:0100:warn:seh:OutputDebugStringA "LowLevelFatalError [File:Unknown] [Line: 242] \nD3DCommandQueue->GetClockCalibration(&GPUTimestamp, &CPUTimestamp) failed \n at t:\\OAK-PATCHWIN64-WIN64\\main\\Engine\\Source\\Runtime\\D3D12RHI\\Private\\D3D12DirectCommandListManager.cpp:320 \n with error E_FAIL\n"
Also tried Proton-tkg 5.22 but same issue there.
Still broken with Proton 5.13-4 and VKD3D 2.1
Tried proton-6.0-ge-1 but the issue still persists. Also there are multiple entries on Protondb with the same issue now.
I think I found the solution. I got suspicious about getting the message "Device does not support VK_VALVE_mutable_descriptor_type" despite using mesa-git. After making sure radv was used and removing amdvlk it suddenly worked. Seems like amdvlk made itself the default for whatever reason.
Only tried dx12 for a short moment so far but performance it pretty amazing.
proton 6.0-ge-1x1 2021-01proton 5.13-4x1 2020-12proton 5.13-2x1 2020-11proton 5.21-ge-1x1 2020-11PROTON_LOG=1x1 2020-11
Borderlands 3 works on the first launch but after that crashes on every launch in DX12 mode with
Deleting GameUserSettings.ini makes the game launch again but it has to be deleted after that again. Also even when running in DX12 mode the game would crash with some DX12 errors on random things like opening the inventory.
DX11 mode works though.
I'm using a RX 5700XT on Arch. Switching between radv, amdvlk and amdgpu pro didn't help.