Are you sure that this is related to vkd3d at all and not just some game quirk?
I am not sure.
Should I close this or just leave it here for reference later?
I don't have this problem with 10875h and RTX5000, also tested on my second laptop with VegaM, no problem at all. With 2.2 version goes from unplayable on VegaM to ~40 fps on 1080p, and game loads like 10 times faster. Just some black magic from devs.
No longer exist on version 2.3.1.
Nothing extracted yet.
The issue starts when you open the menu -> System -> Options then moving between menu items.

It is not really important though but very annoying.
My PC specs: Intel Core i5-9300H, GeForce GTX 1650 (laptop).
Screenshot: