Tropico 4 will crash at start.
Steam Play is enabled for all titles.
My System:
Manjaro 17.1.12
Mesa 18.1.6 with R9 270x
Console Output:

GameAction [AppID 57690, ActionID 2] : LaunchApp changed task to SynchronizingCloud with ""
GameAction [AppID 57690, ActionID 2] : LaunchApp changed task to SiteLicenseSeatCheckout with ""
GameAction [AppID 57690, ActionID 2] : LaunchApp changed task to CreatingProcess with ""
GameAction [AppID 57690, ActionID 2] : LaunchApp waiting for user response to CreatingProcess ""
GameAction [AppID 57690, ActionID 2] : LaunchApp continues with user response "CreatingProcess"
Opted-in Controller Mask: 70
Game update: AppID 57690 "", ProcID 28096, IP 0.0.0.0:0
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.

Adding process 28096 for game ID 57690
GameAction [AppID 57690, ActionID 2] : LaunchApp changed task to WaitingGameWindow with ""
GameAction [AppID 57690, ActionID 2] : LaunchApp changed task to Completed with ""
Adding process 28097 for game ID 57690
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
Adding process 28098 for game ID 57690
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
Adding process 28109 for game ID 57690
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
Adding process 28110 for game ID 57690
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
Adding process 28113 for game ID 57690
Adding process 28115 for game ID 57690
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
Adding process 28118 for game ID 57690
Adding process 28129 for game ID 57690
Adding process 28134 for game ID 57690
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_64/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS64): ignored.
ERROR: ld.so: object '/home/tom/.local/share/Steam/ubuntu12_32/gameoverlayrenderer.so' from LD_PRELOAD cannot be preloaded (wrong ELF class: ELFCLASS32): ignored.
Adding process 28143 for game ID 57690
Game update: AppID 57690 "", ProcID 28109, IP 0.0.0.0:0
Game removed: AppID 57690 "", ProcID 28109
No cached sticky mapping in ActivateActionSet.pid 28111 != 28110, skipping destruction (fork without exec?)