Hello @b3nis, we're using one issue report per unofficially supported game title, and this issue is already being discussed on #2121 starting at https://github.com/ValveSoftware/Proton/issues/2121#issuecomment-534677264. Closing in favor of the existing compatibilty report.
Compatibility Report
System Information
I confirm:
##Proton log
https://gist.github.com/b3nis/0cc4e722324e5013f287a6be22b26896
Symptoms
Getting this error (printscreen) when trying to start the game. I have played it for 25 hours and haven't changed anything (drivers, etc). The only new thing is that Hitman 2 got a new DLC.
Reproduction