Hello @CSahajdacny, what other games are you hearing this issue with? Also, please add PROTON_LOG=1 %command% to the game's launch options and drag and drop the generated $HOME/steam-$APPID.log into the comment box.
Sorry for the time wasted.
It was a hardware issue...
Solved.
Environmental sounds effects, like the music coming from a radio, disappear totally when I move the mouse...
With PROTON 4.11-7 that didn't happen.
Here is an example of what I am writing about with the audio of Borderlands: The Presequel via forced PROTON 4.11-8 when I am the same place of, for example, Moxxi's at Concord, pointing the mouse to different directions... Is not the only game with this audio issue..
Music from speakers loud and clear

Music from speakers is gone (and I am exactly in the same place).
The same problem happen with the voices of NPCs and weapons sounds.
How to download PROTON 4.11-7 or previous?