Hello @dwlyles, we're using one issue report per unofficially supported game title, so I've gone ahead and transferred this issue report to https://github.com/ValveSoftware/Proton/issues/308#issuecomment-704630238.
proton 5.0-9x1 2020-10PROTON_NO_ESYNC=1x1 2020-10WINEDLLOVERRIDES="xaudio2_7=n,b"x1 2020-10
Compatibility Report
System Information
I confirm:
steam-377160.log
Symptoms: Game doesn't launch the fallout 4 launcher. Downloads shaders, never goes to launcher and then stops. Game worked on NTFS for awhile. I then moved the game off the disk and formatted to ext4. Moved the game back with same symptoms. Even went as far as re-downloading 80GBs again but still having the same issue.
I have WINEDLLOVERRIDES="xaudio2_7=n,b" PROTON_NO_ESYNC=1 %command% as launch settings
Tried Proton 5.0-9, 4.11 and 5.9GE.
Reproduction