Adding my two cents, I have played this game on R7 2700X and R9 280X, Manjaro Linux with 86% completion rate several months ago.
There is a regression between Proton 6.3-8 and Proton 7.0-1
This is main menu using Proton 6.3-8:

and main menu (?) using Proton 7.0-1:

The other time this happened is when I try to run DQXI S on my virtualized SteamOS 3 with RX 570 passthrough...
GPU: RX 6700 XT
Distro version: Arch Linux
EDIT: I have confirmed that this problem affects multiple games on my host Arch Linux PC, moving this to https://github.com/ValveSoftware/Proton/issues/5655
Hello @minecraft2048, please add PROTON_LOG=1 %command% to the game's launch options and attach the generated $HOME/steam-$APPID.log to this issue report as a file. (Proton logs compress well if needed.) Also, please copy your system information from Steam (Steam -> Help -> System Information) and put it in a gist, then include a link to the gist in this issue report.
proton 6.3-8x1 2022-03proton 7.0-1x1 2022-03PROTON_LOG=1x1 2022-03
Whitelist Request
System Information
I confirm:
Playbutton in the Steam client is sufficient.Issues
Additional Notes:
Tested as a 100% achievement run solely played on specified machine