first launch with DXVK seems to be your Integrated GPU doesnt handlee vulkan:
err: DxvkAdapter: Failed to create device
I get the same error when trying to run Thunderbird Portable with wine, on ubuntu 20.04.
It makes not difference if the executable is on my flash drive, or on my hard drive.
I get the same error when run my own exe with wine, on Ubuntu 20.04.02.
I get the same error when run my own exe with wine-6.13, Fedora34 running on VMware.
Ooops,It is Chinese below :)
该问题感觉是用户权限问题引起,从winehd用户手册可以看到:

Windows path \??\Z:\ --> Linux path /
所以,应该是当前用户无权访问 / 目录。使用sudo 运行wine即可。
我使用sudo wine my.exe 可以启动我的exe应用,但是由于其他问题,exe运行异常(没有界面),但是没有因为这个报错而异常退出。
Hello @BruceMok, while Proton uses wine internally, vanilla wine installs are not supported here.
You'll want to give your feedback on upstream wine's bug tracker.
Get the same error when run Excel 2010, Ubuntu 20.04. Did anyone solve this problem?
yes
works on my machine
PROTON_USE_WINED3D11=1x1 2021-04PROTON_USE_WINED3D11=1 %command%x1 2021-04
After making a backup of my home folder on Ubuntu, switching over to Arch, and uncompressing the backup, Clicker Heroes 2 fails to work. The game launches with a black screen, but does not load properly. I am using a customized build of the 5.11.11-zen1 kernel and my root partition's file system is BTRFS. I tried deleting the Wine prefix, to no avail.
Log file: steam-629910.log
Update: Game launches fine without using the launch parameter
PROTON_USE_WINED3D11=1 %command%, but runs poorly on Intel HD Graphics. When using this launch option, there is a another error in the log file:fixme:dbghelp:elf_search_auxv can't find symbol in module.Log file when using the
PROTON_USE_WINED3D11=1 %command%launch option: steam-629910.log