Hello @Ilazki, we're using one issue report per unofficially supported game title, so I've gone ahead and transferred this issue report to https://github.com/ValveSoftware/Proton/issues/4894#issuecomment-1052121060.
proton 6.3x1 2022-02proton 7.0x1 2022-02proton experimentalx1 2022-02
Guilty Gear Strive was working well with Proton 6.3, but with Proton 7.0 and Proton Experimental the audio becomes extremely choppy, making the game unplayable under newer Proton versions. Didn't notice any errors or new messages in the console log, so not much useful info to provide beyond that.