Hello @fusselkater, I was able to reproduce this issue. The adjustment to fix #465 is missing the STEAM_RUNTIME_HEAVY environment variable. You can workaround this quirk by setting SteamVR's launch options to STEAM_RUNTIME_HEAVY="${HOME}/.steam/bin64/steam-runtime-heavy" %command%.
It would be better to fold this into the older discussion on #465.
Closing in favor of the older issue report.
Your system information
Please describe your issue in as much detail as possible:
Clicking on settings button on VR Controllers of Valve Index should open the settings overlay but it doesn't. In SteamVR 1.21.4 it worked. Additionally clicking on burger menu -> Settings in SteamVR Dashboard also doesn't work.
Steps for reproducing this issue: