Does it work if you disable nvapi in winecfg?
The game has always worked fine for me in the past even with DXVK's DXGI.
nvapi64 disabled - nothing changes.
Just managed to test it again and the game works fine for me (ignoring input issues, but dxvk has nothing to do with those).
It is on AMD RX, on Mesa ACO from AUR?
Hmm... Maybe it is Wine-TkG problem :-/
Or patch in TkG-dxvk-tools fails somewhere
Hi, I can reproduce this. DXVK 1.3.2.
DXVK's DXGI doesn't start. I have to use Wine's DXGI.
Wine staging 4.14 from Wine's repos https://wiki.winehq.org/Ubuntu.
MassEffectAndromeda_dxgi.log
MassEffectAndromeda_d3d11.log
mea-console-output.txt

Edit: Just a comment. With Proton 4.2, provided by Steam, the game works. But if I change in Lutris to Wine 4.14 staging, the previous error shows up. Both using DLL override dxgi=native.
I can confirm this. Running on Arch Linux 5.3.11-arch1-1 with wine-4.20 (Staging), Nvidia 440.31 and DXVK 1.4.4. I haven't played the game since I had the strange lightning issue, so today I wanted to see if anything had changed since the upgrades both to Nvidia and DXVK.

MassEffectAndromeda_d3d11.log
MassEffectAndromeda_dxgi.log
When I run it with dxgi=native, then it works.
@greencopper can you test this commit: 9e69a610cb1fe5c7bbeef304627dadc9566f2160
I'm still unable to reproduce the problem, but integer overflows might be the issue here.
I'm sorry for my very late reply. I have just upgraded to 1.4.6 this evening and the problem is gone! Thank you very much for your amazing work!
proton 4.2x1 2019-08
Software information
Mass Effect Andromeda launching only with wine's Dxgi
System information
Log files
MassEffectAndromeda_d3d11.log
MassEffectAndromeda_dxgi.log
mealog.txt