Can be also reproduced in the demo with the latest git.
And while tinkering with dxvk cache seems to make a difference sometimes, if I swap back one that seemed working before I can't get it to work again.
Well... nevermind, I'm not able to reproduce this anymore.
I strived to keep everything as close as possible, the only things I can think of different are windows gone from 10.0.19042.746 to 10.0.19042.804 and having DDU'ed the intel driver to 27.20.100.9313 (but not that it should matter here).
Nothing extracted yet.
Software information
Mass Effect 2 1.03, video settings on max. No mods.
System information
Apitrace file(s)
Log files
Somehow, if I fiddle with the hybrid graphics w10 selection tool and the dxvk cache, every now and then I can get the game to boot properly once.