Note: same engine as RE0,RE1 remake
so might be related yes

with that magic DLL the game runs smoothly, better than it ever runned on WIndows natively, that's pure magic and i'll play the game comfortably for the first time in my life, thank you kobin

I sent Kassin a DLL to with direct buffer mapping mode disabled and he confirmed that it fixes the issue. So it is indeed the same problem as #2084.

Can you please send me that file to fix the stuttering? My game is stuttering a lot, and even more using dxvk.

I tried using the latest DXVK version. It seems working fine for a while, but the game still stutters a lot constantly. I've been playing 2 hours now and each new scenario begins to stuttering. Most of the time happens with the flashlight turned on, when I shoot an enemy, some explosion occurs or when I enter to a new room.

Sounds very much like regular shader stutter 👀

Does it go away over time in the same rooms and shooting the same enemies?

Yes and no. If I play the same episode again using dxvk, the game works almost just fine, I'd say even better than the vanilla version. But the stuttering appears here and there occasionally, mostly when I shoot an enemy, opening a door or any explosion occurs. Do I need to play all the game with dxvk to compile the shaders and fix the stuttering? Isn't any way to compile all shaders completely the first time I play it?

Also, I don't see any dxvk_cache file into the game's root. Is that normal?

Do I need to play all the game with dxvk to compile the shaders and fix the stuttering?

To an extent yes since dxvk can't know before it encounters them the shaders that can be compiled into the cache.
Steam shader pre caching should help with some games. But i don't know the details of how well it works between different GPU's, drivers and game updates. Or how often the caches that steam provides are updated.

Also, I don't see any dxvk_cache file into the game's root. Is that normal?

If you have steam shader pre cache enabled then yes that is normal. The cache is instead located in ~/.steam/steam/steamapps/shadercache/ and then the appID of the game. Along with driver caches.
If you turned off shader pre caching a cache file should appear in the games root folder or next to the exe in a sub folder yes.
If more complete caches are avaliable it might help https://github.com/begin-theadventure/dxvk-caches/tree/main/dxvk-caches But i'm not totally sure about that since i don't know technical details.

Isn't any way to compile all shaders completely the first time I play it?

Good news on that front is that recently on the dxvk master branch there have been ongoing work into solving, or helping alot, this issue for a lot of games (it differs). With it, depending on how the game handles it, alot of the shaders should be possible to compile before seeing them directly in the game. Like loading screens or in the main menu. Pre built caches could probably also be provided for that.
Tho at the moment only the nvidia beta vulkan driver supports the extension required for it.

Edit: Note that some games by design do their own internal shader compiling when you play them, which is something that dxvk can't help with.