Sounds like a user error if the DLLs don't get loaded.
Not user error have been using DXVK successfully in dozens of games for years now. Replace the 2.6.2 dll's with the 2.6.1 dll's and everything works again.
Note that 2.6.1 generates log files, if you delete the logs and replace 2.6.1 with 2.6.2 no logs get generated because DXVK isn't being run (and yes I am copying the dll's from the zip files into the games root directory, which is the corrrect location for them for Skyrim SE).
GPU is RTX 3080 Ti 12gb rest as per attachments.
Again, not sure what you're doing but if the DLLs aren't getting loaded, that's not a dxvk issue. It's literally impossible to be our issue when none of our code is even being run. Either you're setting it up the wrong way or the game is picking the system32 ones for... reasons.
Works fine on Proton anyway, as expected.
It's a straight dll replacement of the old version with the new, nothing else. Replacing the new with the old resolves the issue. Literally nothing else is different and the old version 100% works.
In that case I can only recommend sticking to 2.6.1. I don't know why it wouldn't work on your setup, nor do I particularly care since it's clearly an isolated issue. The game literally works fine with 2.6.2 here.
Nothing extracted yet.
Dropping the x64 files into Skyrim SE results in the game dropping back to rendering natively on the GPU and not using DXVK as evidenced by lack of DXVK gui on screen. Skyrim SE works fine with 2.6.1 (using the 64 bit dll files), other games such as Test Drive Unlimited 2 work fine also with the 2.6.2 32 bit dll files.
OS is Windows 10 Pro.