This looks more of a setup issue on your end. DXVK requires those extensions for every game as you can see here:
DxvkExt khrGetPhysicalDeviceProperties2 = { VK_KHR_GET_PHYSICAL_DEVICE_PROPERTIES_2_EXTENSION_NAME, DxvkExtMode::Required };
DxvkExt khrSurface = { VK_KHR_SURFACE_EXTENSION_NAME, DxvkExtMode::Required };
DxvkExt khrWin32Surface = { VK_KHR_WIN32_SURFACE_EXTENSION_NAME, DxvkExtMode::Required };
Not sure what that would be. I use DXVK with Quake Champions on the same prefix with no issues (apart from the known ones)? I also use the same prefix for Crysis and it also works fine. I know that DXVK is working because the diagnostics is in the top left hand corner of the screen.
edit: incorrect reference
This is a setup issue of some sort, and the extensions used/required by DXVK are the same for every game. Please make sure to have both 32-bit and 64-bit Vulkan loaders and drivers set up correctly.
I am adding an additional comment to this in-case someone searches for it in the future. This issue appears to be caused because Ashes ships with vulkan-1.dll in the same directory as the executable.
Renaming this allows the game to progress as expected. Sadly the game doesn't work as it hangs during the loading screen but this appears to be a wine issue and not a DXVK issue.
Oh, the game supports Vulkan?
Have you tried setting vulkan-1.dll to Builtin in winecfg? Should hopefully resolve that issue.
vulkan-1.dllx2 2018-09
When trying to launch Ashes of the Signularity (Escalation) in DX11 mode it fails with the following:
info: Game: AshesEscalation_DX11.exe
info: DXVK: v0.70
warn: OpenVR: Failed to locate module
info: Required Vulkan extension VK_KHR_get_physical_device_properties2 not supported
info: Required Vulkan extension VK_KHR_surface not supported
info: Required Vulkan extension VK_KHR_win32_surface not supported
err: DxvkInstance: Failed to create instance
Not really a bug report, more just to make you are of what extensions some games require.