IIRC there was a shared fence problem with some recent-ish Proton work that would cause these lock-ups, not sure if that's fixed already but you probably want to check proton-experimental or plain old 10.0.
I tried proton experimental and still freezes so doesn't appear fixed.
Well, today i tried with 10.0-4 and the freeze still occurred so maybe it's another thin that causes it.
When playing the game freezes randomly, sometimes just accessing some menus after loading just freezes, other times after playing for a few minutes, other times i can play more than an hour before the freeze
Software information
The witcher 3 GOG using heroic and on dx12. All max with upscaling set to quality. I use optiscaler to use FSR4, but even without it it still freezes. Doesn't matter what upscaler i use to convert to FSR4, or even using with TAAU without upscaling.
Also i tried VKD3D_DISABLE_EXTENSIONS=VK_KHR_present_wait after reading #1638 and doesn't fix it.
System information
Log files
steam-0.log
steam-default.log
I also check for a ring timeout in the system logs, but doesn't have the ring timeout.