Compatibility Report

• Name of the game with compatibility issues: Deus Ex: Mankind dividded
• Steam AppID of the game: 337000

System Information

• GPU: AMD Radeon RX 580 Series (POLARIS10, DRM 3.35.0, 5.4.0-109-generic)
• AMD FX-8350
• Driver/LLVM version: 4.6 (Compatibility Profile) Mesa 21.2.6 / LLVM 12.0.0)
• Kernel version: 5.4.0-109-generic
• Linux Mint 20.3 (64 bit)
• Proton version: Proton Experimental
• X Server Release: 12013000
• X Window Manager: Mutter (Muffin)
• Steam Runtime Version: steam-runtime_0.20220119.0

I confirm:

• [x ] that I haven't found an existing compatibility report for this game.
• [ x] that I have checked whether there are updates for my system available.

Symptoms

After playing some prolonged time the game will freeze, with only music playing and mouse still working, while following error popup shows:
"Microsoft Visual C++ Runtime Li...
Runtime Error!
Program: N:.steam\debian-installati...
R6025
-pure virtual function call"

Reproduction

Intermittent / after prolonged playing (0.5 to 2h), while the game will freeze - probably always, during using, combining, or moving items around a lot inside the inventory

Using starting parameters "env LD_PRELOAD='' DISABLE_VK_LAYER_VALVE_steam_overlay_1=1 %command%", to prevent the notorious stuttering issues otherwise kicking in after some time (see https://github.com/ValveSoftware/Proton/issues/47). But the freeze would seem to occur also without those params.