Your log indicates that dxvk doesn't even get to where it picks an adapter, as that is usually what is printed afterwards.
Does this work with older versions like 1.10.3 or 2.0? I am able to launch correctly on Linux with Proton Experimental with my 7900xtx and radv driver (also if i tell the game i'm on Nvidia)
Indeed, the crash stack shows something wrong at the query adapters step.
No it doesn't seem to work even on older versions (2.0, 1.10.3, 1.9.1 or 1.5.5).
Of note that I just tested on my laptop, with the same results out of the box.
If I disable the 950M though (leaving only the integrated intel graphics) it works.
Given that in #1903 I could confirm everything to be fine, I suspect it's something that nvidia added to their latest (windows?) drivers.
I can confirm the regression happened between 522.30 and 526.47.
(for some reason it doesn't apply to the demo which is just o-kay)
Thank you for nailing down the specific offender
@mirh We do not support piracy here.

The game works fine on Linux with DXVK.
This is either some Windows bullshit that we can do nothing about or an issue with Nvidias Windows Vulkan driver.
if i may add, the game runs fine on windows with dxvk 2.1 with radeon vega 64 on newest 23.2.1 driver.
and as far as i remembered i played the game already with dxvk in 2019 on the same windows setup as well.
I literally said that this problem was introduced in version 526.47.
Also it blows my mind that I cannot even mention the steps that I made "between owning two separate copies of the game".
This is an incompatibility between "whatever the origin DRM triggers in the new nvidia driver" and dxvk.
After much foobaring I found it crashes in this call
https://github.com/doitsujin/dxvk/blob/0d28be4ab8162b6ee2a37d959f5c791e1e69b166/src/dxvk/dxvk_instance.cpp#L176
Enabling all the vulkan loader debug channels couldn't show any difference up to the crash (which happens here).
I also briefly suspected this could be related to the new negotiation changes in the vulkan 1.3.234 loader (as suggested by the name of the topmost function in the stack), but the first affected driver was only 1.3.224.
FWIW this still happens in yesterday's 531.18.
This got fixed in nvidia 555.99 drivers.
proton experimentalx1 2023-02combase.dllx1 2023-02d3d9.dllx1 2023-02nvoglv32.dllx1 2023-02vulkan-1.dllx1 2023-02
Software information
Mass Effect 2, any setting.
I verified both DXVK to work with other games, and other wrappers to work with ME2.
System information
Apitrace file(s)
Log files